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Inform Canadians of the evidence linking Crohn's disease to Mycobacterium Avium Paratuberculosis and Johne's disease in animals
 
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Intestinal t cells from CD patients react to MAP

 
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david.crichton



Joined: 02 May 2008
Posts: 83
PostPosted: Tue May 26, 2009 3:18 am    Post subject: Intestinal t cells from CD patients react to MAP Reply with quote
Intestinal t cells from CD patients react more vigorously to MAP than to commensal bacteria, and react more vigorously to MAP when compared to UC or controls' intestinal t cells.

Note the discussion of NOD2 and MDP, which is present in bacterial cell walls, and how mycobacteria produce a 'special' form of MDP that is more potent at inducing pro-inflammatory responses.  And how cows with NOD2 polymorphism more susceptible to MAP infection.  So think about it: 95-99% of people with NOD2 do not develop disease, and yet they all have commensal bacteria; must there not be something else required other than commensal bacteria to trigger disease?











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