crohnscanada.myfastforum.org

jd12 · Joined: 01 Apr 2008 Posts: 1

http://www.medwire-news.md/41/747...species_link_to_CD_supported.html

Too bad MAP was only found in 1/3 of Crohn's patients. Mad

david.crichton · Joined: 02 May 2008 Posts: 27

Interesting, thanks very much for posting.

It was a small proportion of Crohn's patients to have been found to be MAP DNA positive. But there have been other studies - two recent meta-analyses comprising stats from many other individual studies - which you maybe already know about anyways, that showed a higher odds ratio; at least one of them and maybe the other too showed an odds ratio of 7 - a higher association than any genetic factors yet reported. Also, some doctors have said that the DNA PCR is less likely to get all positive patients than are fresh biopsy samples. Also, if Greenstein et al.'s finding that current Crohn's drugs like 5-ASA and Methotrexate have activity against MAP in vitro means that they have activity against MAP in vivo too then maybe that could explain the lower end proportion of Crohn's patients to have been found to be MAP DNA positive. I guess someone should follow up on Greenstein et al.'s work and do tests with the drugs and MAP ex vivo. Also, there is the possibility that Crohn's has numerous causes - maybe other bacteria or viruses. Nonetheless, a lot of evidence shows that MAP does cause Crohn's in a subset of patients - how big that subset actually is?...

Thanks again for the link.

Exploited · Joined: 24 Jan 2008 Posts: 41

I had read MAP mainly resides in the lymphatic system.
Taylor is saying he is finding it in 95% of patients.
And there testing isn't accurate, they still to this day do not have particularly accurate TB, or Leprosy blood tests.

With the amount of proof Taylor has, they are just wasting time and money re-inventing the wheel.