david.crichton
Joined: 02 May 2008
Posts: 83
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 Posted: Tue Aug 12, 2008 12:00 pm Post subject: |
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Very interesting. Thanks. I am taking oil of oregano; good to know it has some anti-MAP properties. Maybe need to load up on cinnamon too.
If anyone knows, how do these concentrations carry over to in vivo. I mean, I believe this study and others using 5-ASA and Methotrexate for instance were all in vitro in just a medium in a dish, so they didn't have to filter through the body or get into cells where MAP live. How much of these naturally-occurring compounds would you need to take to achieve these concentrations inside of your cells, assuming that these compounds would be taken up by your immune cells?
These compounds, as far as I understand, don't appear to be as strong as some antibiotics or some "anti-inflammatory" or "immune-suppressant" drugs; that is, they require higher concentrations (with the exception of 5-ASA compared to some of the natural compounds), to inhibit MAP growth. But can you achieve much higher concentrations of the natural compounds than you can with the drugs, and without the side effects too? It would be really interesting to know.
Here are a couple abstracts from the drug in vitro trials. Notice the low concentrations required for clarithromycin and methotrexate to inhibit MAP growth. In Collins' article they mention that using some drugs in concert may change the effects those drugs normally have on MAP, potentially for the negative I believe - complicated craziness. They said that "Antimycobacterial and thiopurine drugs used in concert may produce an interactive effect. The apparently bacteriostatic effects of 6-MP on M. paratuberculosis rendered the organism less susceptible to the bactericidal effects of CIP [Ciprofloxacin]."
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